产品详情;
CasNo： 375815-87-5
分子式： C17H19N3O6
外观： colourless viscous liquid
交货时间： In stock
生产能力： 10000|Metric Ton|Month
技术指标： 99%
| Varenicline tartrate Basic information |
| Product Name: | Varenicline tartrate |
| Synonyms: | VARENICLINE TARTRATE;Varenicline tartrate for research;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate;Champix;CP 526555-18;Varenicline Tartarate;CS-291;,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro- |
| CAS: | 375815-87-5 |
| MF: | C17H19N3O6 |
| MW: | 361.34926 |
| EINECS: | 638-780-5 |
| Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Heterocyclic Compounds;APIs;Chantix, Champix;Inhibitors;Pharmaceuticals;Pfizer compounds |
| Mol File: | 375815-87-5.mol |
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| Varenicline tartrate Chemical Properties |
| Melting point | 206-208°C |
| storage temp. | room temp |
| solubility | DMSO: >5mg/mL |
| form | powder |
| color | white to beige |
| InChIKey | TWYFGYXQSYOKLK-UHFFFAOYSA-N |
| Safety Information |
| Hazard Codes | Xn,N,T,F |
| Risk Statements | 22-50-39/23/24/25-23/24/25-11 |
| Safety Statements | 22-57-45-36/37-16-7 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| MSDS Information |
| Varenicline tartrate Usage And Synthesis |
| Chemical Properties | Tan Solid |
| Uses | Nicotinic a4 acetylcholine receptor partial agonist. Aid in smoking cessation. |
| Uses | Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation. |
| Uses | Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther |
| Definition | ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking. |
| Brand name | Chantix (Pfizer). |
| Biological Activity | Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo . |
| Biochem/physiol Actions | Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking. |
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