18342-66-0
- Product Name:2,5-Pyrrolidinedione,1-[[(methylamino)carbonyl]oxy]-
- Molecular Formula:C6H8N2O4
- Purity:99%
- Molecular Weight:
Product Details;
CasNo: 18342-66-0
Molecular Formula: C6H8N2O4
Henan Wentao Chemical Product Co., Ltd. is a quality supplier and manufacturer of N-Succinimidyl-N-methylcarbamate . We export high quality 2,5-Dioxopyrrolidin-1-yl methylcarbamate 18342-66-0.
High Quality 2,5-Dioxopyrrolidin-1-yl methylcarbamate 18342-66-0 Export
- Molecular Formula:C6H8N2O4
- Molecular Weight:172.141
- Melting Point:148-153 °C
- Refractive Index:1.527
- PKA:11.00±0.46(Predicted)
- PSA:75.71000
- Density:1.416 g/cm3
- LogP:-0.26480
18342-66-0 Usage
2,5-Dioxopyrrolidin-1-yl methylcarbamate, as known as N-succinimidyl N-methylcarbamate (NSNM), is a surrogate chemical containing a functional isocyanate group. It is used as a reagent in the synthesis of Argifin, a natural product chitinase inhibitor with chemotherapeutic potential. 2,5-Dioxopyrrolidin-1-yl methylcarbamate is also used as a reagent in the preparation of 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide (A616300); a metabolite of Temozolomide (T017775) which is an imidazotetrazine alkylating agent and antineoplastic.
InChI:InChI=1/C6H8N2O4/c1-7-6(11)12-8-4(9)2-3-5(8)10/h2-3H2,1H3,(H,7,11)
2,5-Dioxopyrrolidin-1-yl methylcarbamate 18342-66-0 Relevant articles
Synthesis and in vitro antitumor activity of novel 2-alkyl-5- methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives
Mori, Ryota,Kato, Asako,Komenoi, Kousuke,Kurasaki, Haruaki,Iijima, Touru,Kawagoshi, Masashi,Kiran,Takeda, Sho,Sakai, Norio,Konakahara, Takeo
, p. 16 - 35 (2014/06/09)
Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.
Recent Advances in the Chemistry and Biological Activity of Sulfonamide Derivatives
Yousif, Mahmoud N.M.; El-Gazzar, Abdel-Rahman B.A.; Hafez, Hend N.; Fayed, Ahmed A.; ElRashedy, Ahmed; Yousif, Nabil M.
, Mini-Reviews in Organic Chemistry, Volume 19, Number 6, 2022, pp. 695-707(13)
Compound 67 reacted with 2,5-dioxopyrrolidin-1-yl methylcarbamate to afford compound 71 [27] (Scheme 12). Compound 67 reacts with amine derivative to afford compound 70. Gallic …
Assessment of the Biological Pathways Targeted by Isocyanate Using N-Succinimidyl N-Methylcarbamate in Budding Yeast Saccharomyces cerevisiae
Gajendra Kumar Azad,Vikash Singh,Raghuvir S. Tomar
, PLoS One, 2014
N-succinimidyl N-methylcarbamate (NSNM) is one of the carbamate esters which possess functional isocyanate group. N-methyl carbamates are a group of organic compounds which share a common functional group with the general structure –NH(CO)O–.
18342-66-0 Process route
- 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione
- 624-83-9
methyl isocyanate
- 18342-66-0
2,5-dioxopyrrolidin-1-yl methylcarbamate
Conditions | Yield |
---|---|
With triethylamine; In ethyl acetate; at 0 - 20 ℃; for 24h;
|
86% |
With pyridine; for 24h; Ambient temperature;
|
80% |
With triethylamine; In tetrahydrofuran; 1.) 60-80 deg C, 4 h, 2.) RT, overnight;
|
- 15149-73-2
2,5-dioxopyrrolidin-1-yl carbonochloridate
- 593-51-1
methylamine hydrochloride
- 18342-66-0
2,5-dioxopyrrolidin-1-yl methylcarbamate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 3 ℃; for 48h;
|
80% |
18342-66-0 Upstream products
-
6066-82-6
1-hydroxy-pyrrolidine-2,5-dione
-
624-83-9
methyl isocyanate
-
15149-73-2
2,5-dioxopyrrolidin-1-yl carbonochloridate
-
593-51-1
methylamine hydrochloride
18342-66-0 Downstream products
-
80354-48-9
N-methyl-N-nitrosocarbamic acid N'-hydroxysuccinimide ester
-
243975-37-3
cyclo(Nw-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalanyl-β-L-aspartyl-β-L-aspartyl-D-alanyl)
-
57-47-6
(+/-)-Physostigmine
-
857275-30-0
benzyl (3R,4R)-3-{7-bromo-3-methyl-1-[2-(3-methylureido)ethyl]-1H-indol-6-ylmethoxy}-4-{4-[3-(2-methoxybenzyl)oxypropoxy]phenyl}piperidine-1-carboxylate
Relevant Products
-
N,N'-1,3-Phenylene bismaleimide
CAS:3006-93-7
-
1-Dodecanaminium,N,N,N-trimethyl-, bromide (1:1)
CAS:1119-94-4
-
Pyridinium,1-hexadecyl-, chloride, hydrate (1:1:1)
CAS:6004-24-6