3034-50-2
- Product Name：1H-Imidazole-4-carbaldehyde
- Molecular Formula：C4H4N2O
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 3034-50-2
Molecular Formula： C4H4N2O
Appearance： White to light yellow powder
1H-Imidazole-4-carbaldehyde 3034-50-2 In Stock, Factory Price
- Molecular Formula:C4H4N2O
- Molecular Weight:96.0886
- Appearance/Colour:White to light yellow powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:174-177 °C(lit.)
- Refractive Index:1.535
- Boiling Point:367.8 °C at 760 mmHg
- PKA:11.05±0.10(Predicted)
- Flash Point:179.8 °C
- PSA：45.75000
- Density:1.322 g/cm3
- LogP:0.22220
3034-50-2 Usage
Chemical Properties
White to light yellow powder
Uses
1H-Imidazole-4-carbaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatemnet of androgen-dependent prostate cancer. 4-Imidazolecarboxaldehyde is also used in the synthesis of other biologically active compounds such as antimalarial drugs.
Uses
Imidazole-4-carboxaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatment of androgen-dependent prostate cancer. It is also used in the synthesis of other biologically active compounds such as antimalarial drugs, fabrication of colorimetric chemosensor.
Chemical Properties
White to light yellow powder
Uses
1H-Imidazole-4-carbaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatemnet of androgen-dependent prostate cancer. 4-Imidazolecarboxaldehyde is also used in the synthesis of other biologically active compounds such as antimalarial drugs.
Uses
Imidazole-4-carboxaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatment of androgen-dependent prostate cancer. It is also used in the synthesis of other biologically active compounds such as antimalarial drugs, fabrication of colorimetric chemosensor.
InChI:InChI=1/C5H6N2O/c1-4(8)5-2-6-3-7-5/h2-3H,1H3,(H,6,7)
3034-50-2 Relevant articles
Regioselective n-alkylation of 4-formylimidazole
Su, Qiaogong,Wood, Jeffery L.
, p. 3383 - 3389 (2000)
We describe here a high yield and highly regioselective N-alkylation of 4-formylimidazole via reversible Michael Reaction.
Urocanic acid photobiology. Purine-assisted photooxidation to 1H- imidazole-4(5)-carboxaldehyde
Mohammad,Kasper,Morrison
, p. 4903 - 4906 (1994)
Urocanic acid undergoes photooxidative cleavage at the acrylic acid side chain to afford imidazole carboxaldehyde. The reaction is accelerated in the presence of purines. Evidence is presented that the photooxidation involves a reaction of the UA radical cation and ground state molecular oxygen.
A simple and efficient synthesis of N-protected imidazole-4-carbaldehyde
Winter,Retey
, p. 245 - 246 (1994)
Successive addition of BuLi, triethylsilyl chloride, s-BuLi and DMF to 1- (N,N-dimethylsulfamoyl)imidazole (1) yields pure 1-(N,N-dimethylsulfamoyl)- 2-(triethylsilyl)imidazole-4-carbaldehyde (2) as judged by 1H NMR spectroscopy. Treatment of 2 with 2 N HCl leads to free imidazole-4- carbaldehyde (3) (overall yield 70.2%).
-
Brocklehurst,Griffiths
, p. 2407 (1968)
-
Method for preparing 1H-imidazole-4-carbonitrile
-
Paragraph 0034; 0043-0049, (2019/02/26)
The invention discloses a method for preparing 1H-imidazole-4-carbonitrile, and particularly relates to the technical field of fine chemical product preparation. The method for preparing 1H-imidazole-4-carbonitrile comprises the following steps: step (1) oxidation reaction: performing oxidation on 4-hydroxymethylimidazole to obtain 1H-imidazole-4-carboxaldehyde; step (2) oximation reaction: performing oximation reaction on the 1H-imidazole-4-carboxaldehyde prepared in the step (1) to obtain 4-formaldoximido imidazole; and step (3) dehydration reaction: performing dehydration reaction on the 4-formaldoximido imidazole prepared in the step (2) to obtain 1H-imidazole-4-carbonitrile. The method provided by the invention has the advantages of reducing many steps due to intermediates are not purified from the beginning of the reaction to the end of the process, reducing energy consumption due to high and low temperature equipment is not used, reducing environmental pollution due to acidic wastewater is not generated, and having a high yield of products; the invention proposes a complete process route for synthesizing 1H-imidazole-4-carbonitrile by using 4-hydroxymethylimidazole as a rawmaterial; and the method is simple in process and easy to realize industrial production.
Synthesis method of 1H-imidazole-4-carboxylic acid
-
Paragraph 0021; 0028; 0035; 0042; 0049, (2018/05/16)
The invention discloses a synthesis method of 1H-imidazole-4-carboxylic acid. The method comprises steps as follows: (1) a hydrochloric acid solution is added to a reaction kettle, chromium trioxide is added under the stirring condition, the mixture is stirred uniformly and heated to 40-50 DEG C, pyridine is dropwise added, the mixture is stirred to react for 2-3 h after pyridine is dropwise added, PCC (pyridinium chlorochromate) is prepared, TiO2 is added, a dichloromethane solution of 4-methylimidazole is dropwise added under the stirring condition, the mixture is subjected to a reaction at40-50 DEG C for 3-4 h, then, filtration and centrifugation are performed, an organic layer is collected, reduced pressure distillation is performed, and 1H-imidazole-4-formaldehyde is prepared; (2) prepared 1H-imidazole-4-formaldehyde and dichloromethane are mixed, the obtained mixture is heated to 40-50 DEG C, KMnO4 is added, the mixture is mixed uniformly and stirred for a reaction for 3-4 h, filtration, reduced pressure distillation and recrystallization are performed, and 1H-imidazole-4-carboxylic acid is prepared. The synthesis method is simple to operate and mild in condition, fewer by-products are produced, the product purity is high and the product yield is higher.
Hydrazinyl-Substituted Heteroaryl Compounds and Methods for Producing a Conjugate
-
Paragraph 0540-0542, (2017/09/29)
The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
Halogen–metal exchange on bromoheterocyclics with substituents containing an acidic proton via formation of a magnesium intermediate
Tian, Qingqiang,Shang, Suqin,Wang, Huajun,Shi, Guoqiang,Li, Zhiyao,Yuan, Jianyong
supporting information, (2017/12/05)
A selective and practical bromine–metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. Our protocol of using a combination of i-PrMgCl and n-BuLi has not only solved the problem of intermolecular quenching that often occurred when using alkyl lithium alone as the reagent for halogen–lithium exchange, but also offered a highly selective method for performing bromo–metal exchange on dibrominated arene compounds through chelation effect.
3034-50-2 Process route
-
- 3465-72-3
urocanic Acid
-
- 645-65-8
2-(1H-imidazol-4-yl)acetic acid
-
- 3034-50-2
4(5)formylimidazole
-
- 1072-84-0
imidazole-4-carboxylic acid
| Conditions | Yield |
|---|---|
|
With dihydrogen peroxide; pH=7.2; Product distribution / selectivity; aqueous phosphate buffer;
|
|
|
With dihydrogen peroxide; In water; pH=7.2; Product distribution / selectivity;
|
-
- 3465-72-3
urocanic Acid
-
- 645-65-8
2-(1H-imidazol-4-yl)acetic acid
-
- 3034-50-2
4(5)formylimidazole
-
- 1072-84-0
imidazole-4-carboxylic acid
-
- 7699-35-6
(Z)-urocanic acid
| Conditions | Yield |
|---|---|
|
With dihydrogen peroxide; pH=7.2; Product distribution / selectivity; aqueous phosphate buffer; UV-irradiation;
|
3034-50-2 Upstream products
-
822-55-9
(1H-imidazol-4-yl)methanol
-
822-55-9
1H-imidazole-5-methanol
-
32673-41-9
1H-imidazol-5-ylmethanol hydrochloride
-
853803-63-1
tert-butyl 5-formyl-1H-imidazole-1-carboxylate
3034-50-2 Downstream products
-
3465-72-3
urocanic Acid
-
39021-62-0
1-methylimidazole-5-carbaldehyde
-
67565-89-3
5-methyl-3-phenyl-isoxazole-4-carboxylic acid (1(3)H-imidazol-4-ylmethylene)-hydrazide
-
108320-28-1
8-(4-Methylphenylsulfonyl)-5H-imidazo<1,5-a>azepin
Relevant Products
-
N,N'-1,3-Phenylene bismaleimideCAS：3006-93-7
-
-
ferric acetateCAS：10450-55-2
