Product classification

66335-38-4

Product Name：5'-Deoxy-5-fluorocytidine
Molecular Formula：C₉H₁₂FN₃O₄
Purity：99%
Molecular Weight：

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Product Details;

CasNo： 66335-38-4

Molecular Formula： C₉H₁₂FN₃O₄

Appearance： White solid

High Purity 5-Deoxy-5-fluorocytidine 66335-38-4 With Best Price

Molecular Formula:C9H12FN3O4
Molecular Weight:245.21
Appearance/Colour:White solid
Melting Point:196-198 °C
Boiling Point:437.874 °C at 760 mmHg
PKA:13.65±0.70(Predicted)
Flash Point:218.619 °C
PSA：110.60000
Density:1.841 g/cm³
LogP:-0.81510

5-Deoxy-5-fluorocytidine 66335-38-4 In Medicine Usage

Chemical Properties

White Solid

Uses

A metabolite of Capecitabine

Uses

A metabolite of Capecitabine.

66335-38-4 Relevant articles

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

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Paragraph 00166, (2018/02/03)

The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII and, the methods for the treatment of cancer and infectious diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cancer, neoplasm, infections and skin diseases.

NOVEL SYNTHESIS OF 5-DEOXY-5'-FLUOROCYTIDINE COMPOUNDS

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Paragraph 0030; 0031, (2013/07/25)

This invention relates to a process of synthesizing a β-nucleoside compound of formula (I): wherein R1 is alkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl. The process includes reacting a compound of formula (II): with a compound of formula (III): wherein R1 is as defined above and X is chloride, bromide, iodide, methanesulfonate, triflate, p-toluenesulfonate, trifluoroacetate, 4-nitrophenoxy, or N-succinimidyloxy, in a solvent and in the presence of a base.

Design, synthesis and anti-tumoractivity of novel amidine derivatives of doxifluridine

Feng, Ji Lu,Sun, Hai Ling,Geng, Dong Ping,Li, Ke

scheme or table, p. 163 - 166 (2010/11/18)

A series of novel amidine derivatives of doxifluridine were synthesized using acid amide as the starting material, and their anti-tumor activity was evaluated in A549 cells. Compounds 10 and 11 demonstrated were more potent than 5-Fu, which was used as a positive control. Compound 10, which were found to be the most potent one with IC50 of 3.2 μmol/L, was 16 times more potent than 5-Fu with IC50 of 52 μM to the A549 cells. A new route was designed to synthesize 5′-deoxy-5-fluorocytidine. All compounds were characterized by 1H NMR, MS and X-ray spectras in detail.

Process for the preparation of capecitabine

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Page/Page column 9-10, (2009/09/05)

The present application relates to an improved process for the preparation of capecitabine.

66335-38-4 Process route

: 124012-42-6
5'-deoxy-5-fluoro-N⁴-(3,4,5-trimethoxybenzoyl)cytidine

: 3086-62-2
3,4,5-trimethoxybenzamide

: 66335-38-4
5'-deoxy-5-fluorocytidine

: 118-41-2
Eudesmic acid

: 69260-71-5,71609-07-9,71609-60-4,76462-79-8,106775-49-9,106775-50-2,106775-51-3,3094-09-5
doxifluridine

Conditions

Conditions	Yield
With sodium chloride; In acetonitrile; at 37 ℃; for 168h; Product distribution; var. pHs;

: 154361-50-9,158798-73-3
capecitabine

: 66335-38-4
5'-deoxy-5-fluorocytidine